Manipulation of CD98 Expression Affects both Trophoblast Cell Fusion and Amino Acid Transport Activity during Syncytialization of Human Placental BeWo Cells
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چکیده
منابع مشابه
Carrier-mediated transport of valproic acid in BeWo cells, a human trophoblast cell line.
The biochemical mechanisms mediating the rapid distribution of valproic acid across placenta are not precisely known. We have characterized valproic acid transport by the human trophoblast using the human choriocarcinoma cell line, BeWo. The uptake of [14C]valproic acid by BeWo cells was found to be saturable and blocked by pre-exposure to the metabolic inhibitors, sodium azide and 2,4-dinitrop...
متن کاملCortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo).
Both placental system A activity and fetal plasma cortisol concentrations are associated with intrauterine growth retardation, but it is not known if these factors are mechanistically related. Previous functional studies using hepatoma cells and fibroblasts produced conflicting results regarding the regulation of system A by cortisol. Using the b30 BeWo choriocarcinoma cell line, we investigate...
متن کاملKrüppel-Like Factor 6 Expression Changes during Trophoblast Syncytialization and Transactivates ßhCG and PSG Placental Genes
BACKGROUND Krüppel-like factor-6 (KLF6) is a widely expressed member of the Sp1/KLF family of transcriptional regulators involved in differentiation, cell cycle control and proliferation in several cell systems. Even though the highest expression level of KLF6 has been detected in human and mice placenta, its function in trophoblast physiology is still unknown. METHODOLOGY/PRINCIPAL FINDINGS ...
متن کاملH(+)-linked transport of salicylic acid, an NSAID, in the human trophoblast cell line BeWo.
We investigated the transport of salicylic acid and L-lactic acid across the placenta using the human trophoblast cell line BeWo. We performed uptake experiments and measured the change in intracellular pH (pH(i)). The uptakes of [(14)C]salicylic acid and L-[(14)C]lactic acid were temperature- and extracellular pH-dependent and saturable at higher concentrations. Both uptakes were also reduced ...
متن کاملHeme-mediated apoptosis and fusion damage in BeWo trophoblast cells
Placental malaria (PM) is a complication associated with malaria infection during pregnancy that often leads to abortion, premature delivery, intrauterine growth restriction and low birth weight. Increased levels of circulating free heme, a by-product of Plasmodium-damaged erythrocytes, is a major contributor to inflammation, tissue damage and loss of blood brain barrier integrity associated wi...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2003
ISSN: 0022-3751,1469-7793
DOI: 10.1113/jphysiol.2003.040550